"in mice, semaglutide reduced the size of the heart's left ventricle, the overall heart weight, and the surface area of heart cells. In cultured human heart cells, semaglutide had the same effect, "
I would be cautious as there are no longer term studies on these drugs. I would hate to see a bunch of people come up with cardio issues, much like many drugs that later turn out to be risky.
I take a supplement called Luteolin (for asthma), which has dropped my weight, along with having a protein smoothie in the morning. This supplement will also reduce your blood sugar level, so one should be aware about glucose levels. There is a supplement, a nutraceutical named Altilix® which uses artichoke extract with luteolin in it.
This study below, is worth a read as the differences systemically are very beneficial to your hepatic, blood sugar, insulin resistance, LDL, ghrelin levels, vascular modeling, and inflammation markers. I may switch. On edit, this brand supplement is not available here in the states. They use cardoon extract. The artichoke leaf and extract most readily available is Globe artichoke, which is also good to use. That you can get easily. The compounds in the extract are
chlorogenic acid and its derivatives, and luteolin and its derivatives as well as others.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6893885/
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